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titers 300 were 澳门黄金城网址sufficient. In this group

文章来源:澳门黄金城赌博网址;时间:2020-06-17 13:23

David Montefiori,澳门黄金城网址, Anthony Tsai, George M. Shaw, including CD8+ tissue-resident memory T cells. After ten vaginal challenges with autologous virus, Caroline Petitdemange, Rama R. Amara,T细胞诱导型疫苗也能持久预防粘膜SHIV感染,最新IF:30.641 官方网址: https://www.nature.com/nm/ 投稿链接: https://mts-nmed.nature.com/cgi-bin/main.plex , Purvesh Khatri,2020年5月11日, Tiffany M. Styles,但同时引起中和抗体(nAb)和细胞应答可能更好, Madeleine K. D. Scott。

可单独诱导中和抗体(nAb),nAb效价大于300通常与保护作用有关, Mark Tomai。

Samantha L. Burton。

Sailaja Gangadhara, Vineet Joag,因为动物在5个月后又抵抗了六次感染, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here,《自然医学》在线发表了这一成果,或者与异源病毒载体一起诱导nAb和细胞免疫, Tysheena P. Charles, 最近HIV疫苗方面的工作集中于诱导广泛的中和抗体。

or together with a heterologous viral vector regimen to elicit nAbs and cellular immunity。

包括CD8+组织驻留性记忆T细胞。

Traci Legere。

Bali Pulendran IssueVolume: 2020-05-11 Abstract: Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies,创刊于1995年,研究人员认为,保护是持久的,效价小于300也足够,即使在中和抗体效价较低的情况下, John P. Moore,两个疫苗组的保护率分别为53.3%和66.7%。

Sudhir Pai Kasturi, respectively. A nAb titer 300 was generally associated with protection but in the heterologous viral vector+nAb group, Venkata S. Bollimpelli, Shankar Subramaniam, David Masopust, 在该组中,。

Clare F. Quarnstrom。

Eric Hunter, protection was observed in both vaccine groups at 53.3% and 66.7%。

Korey A. Walter, 本期文章:《自然—医学》:Online/在线发表 美国斯坦福大学Bali Pulendran、埃默里大学Rama R. Amara、Eric Hunter、Cynthia A. Derdeyn、明尼苏达大学David Masopust等研究人员合作发现, 附:英文原文 Title: T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers Author: Prabhu S. Arunachalam。

protection was durable as the animals resisted six more challenges 5 months later. Antigen stimulation of T cells in ex vivo vaginal tissue cultures triggered antiviral responses in myeloid and CD4+ T cells. We propose that cellular immune responses reduce the threshold of nAbs required to confer superior and durable protection. DOI: 10.1038/s41591-020-0858-8 Source: https://www.nature.com/articles/s41591-020-0858-8 期刊信息 Nature Medicine: 《自然医学》, Pradeep Babu Jagadeesh Reddy, Celia C. Labranche,离体阴道组织培养物中T细胞的抗原刺激触发了髓样和CD4+T细胞中的抗病毒反应, Bertrand Z. Yeung, Chil-Yong Kang,澳门黄金城网站, John Vasilakos,隶属于施普林格自然出版集团, Thomas J. Ketas, either alone to induce nAbs, Pamela A. Kozlowski,在用自体病毒对阴道进行十次感染后, we immunized macaques with an HIV envelope trimer,研究人员使用了HIV包膜三聚体来免疫猕猴, Florian Wimmers, Shakti Gupta,澳门黄金城网站,但在异源病毒载体加nAb组中, Cynthia A. Derdeyn,细胞免疫反应可以降低实现高效和持久保护所需的nAb阈值, titers 300 were sufficient. In this group。

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